الخوجة

 ظهرت ◄نتيجة الشهادة الابتدائية بالقاهرة ........ اعرف نتيجتك من هنا نتيجة ابتدائية القاهرة أوائل الشهادة الابتدائية لمحافظة القاهرة 2015 نتيجة ابتدائية القاهرة | نتيجة الشهادة الابتدائية بالقاهرة | نتيجة الصف السادس الابتدائى  القاهرة بوابة نتائج الطلاب بالقاهرة    نتائج الخوجة,نتيجة الشهادة الابتدائية جميع المحافظات,نتيجة الصف السادس الابتدائى جميع المحافظات ---------------------------

Trouble with Sovaldi, Or Not? I wish that this were some sort of April Fool's entry, but it isn't. There appears to be an outside chance that Gilead's huge-selling Sovaldi (sofosbuvir) for hepatitis C has some cardiovascular problems. There have been a few reports from the field, and the FDA has asked for a label change when the drug is used in patients who have taken amiodarone . But this commentary at Medscape is arguing that the problem might be bigger. The amiodarone interaction could be explained by inhibition of PGP, changing the pharmacokinetics of Sovaldi in some susceptible patients. (Amiodarone has odd PK and a particularly long half-life, raising the chances that you might see something). And/or there could be something intrinsic to sofosbuvir, and that's the open question (the kind of question you can really only answer once a drug's on the market). There's a large patient population taking the drug, and getting larger all the time...